During the French War of Religion, Protestant coup officials in Nîmes massacre Catholic priests in an event now known as the Michelade.

The French Wars of Religion were a series of civil wars between French Catholics and Protestants from 1562 to 1598. Between two and four million people died from violence, famine or disease directly caused by the conflict, and it severely damaged the power of the French monarchy. The fighting ended with a compromise in 1598, when Henry of Navarre, who converted to Catholicism in 1593, was proclaimed King Henry IV of France and issued the Edict of Nantes, which granted substantial rights and freedoms to the Huguenots. However, Catholics continued to disapprove of Protestants and of Henry, and his assassination in 1610 triggered a fresh round of Huguenot rebellions in the 1620s.