The first attacks of the Tuscarora War begin in present-day North Carolina.

The Tuscarora War was fought in North Carolina from September 10, 1711, until February 11, 1715, between the Tuscarora people and their allies on one side and European American settlers, the Yamasee, and other allies on the other. This was considered the bloodiest colonial war in North Carolina. The Tuscarora signed a treaty with colonial officials in 1718 and settled on a reserved tract of land in Bertie County, North Carolina. The war incited further conflict on the part of the Tuscarora and led to changes in the slave trade of North and South Carolina.