The first European school of higher learning in the Americas, Colegio de Santa Cruz de Tlatelolco, is founded by Viceroy Antonio de Mendoza and Bishop Juan de Zumárraga in Mexico City.

The Colegio de Santa Cruz in Tlatelolco, Mexico City, is the first and oldest European school of higher learning in the Americas and the first major school of interpreters and translators in the New World. It was established by the Franciscans on January 6, 1536, with the intention, as is generally accepted, of preparing Native American boys for eventual ordination to the Catholic priesthood. Students trained in the Colegio were important contributors to the work of Franciscan Bernardino de Sahagún in the creation of his monumental twelve-volume General History of the Things of New Spain, often referred to as the Florentine Codex. The failure of the Colegio had long-lasting consequences, with scholar Robert Ricard saying that "[had] the College of Tlatelolco given the country even one [native] bishop, the history of the Mexican Church might have been profoundly changed."