The Universidad Santo Tomás de Aquino is founded in what is now the Dominican Republic.

The University of St. Thomas Aquinas is, from a historical perspective, the first university founded in the Americas. It was established by the papal bull In Apostolatus Culmine, issued by Pope Paul III on October 28, 1538, at a time when royal approval through a "pase regio" was not yet required. It was later officially recognized by the Spanish Crown through a Royal Provision on February 23, 1558. Its main headquarters were located in the Church and Convent of the Dominicans.